"A healthy mouth, makes a pleasant and functional
social message positive and reassuring."

dc. Maurizio Serafini



Topic: Periodontology

Authors: INCHINGOLO Francesco1-2, PUGLIESE Adalisa1, MARRELLI2 Massimo, TATULLO Marco1,2, INCHINGOLO Angelo Michele3, POLI Gaetano,INCHINGOLO4 Alessio Danilo1-4, SCHINCO Fabio1-4, MARINELLI Grazia1, CERRUTI QUARA Piero1-4, MUOLLO Ferdinando1-4, RESTA Gianpiero 1-4, SERAFINI Maurizio4, DIPALMA Gianna 1,2.
1 University of Bari. Interdisciplinary Department of Medicine
2 Calabrodental casa di cura and Tecnologica research. Crotone
3 University of Milano-Bicocca
4 Freelance professional

Platelet-rich plasma (PRP) is blood plasma whose rationale is that platelets release different substances promoting tissue repair and affect the behavior of other cells and modulate inflammation and angiogenesis. Platelets, in fact, play a fundamental role in mediating the healing of damaged tissue thanks to their ability to release growth factors, such as PDGF, TGF β, VEGF, IGF-1, FGF, and EGF. Therefore, PRP can be used in those surgical areas where a faster tissue regeneration is required.
The aim of this work is to stimulate the physiological mechanisms of tissue regeneration, bone regeneration in particular, increasing their concentration in the implant sites.

In the present work, nine male patients aged between 28 and 55 years and two females patients were treated. They presented with several problems: three of them with radicular cystic lesions, unscrewed prosthesis, destruction of the bone saddle due to a periodontal disease and severe atrophy of the jaw.
After objective structured clinical examination and radiological and periodontal examinations, PRP in combination with small amounts of autologous bone was used to solve these problems. It was obtained with a double-centrifugation technique, characterized by the decrease of platelet stressors according to the shortness of centrifugation time and the level of revolutions applied. After adding PRP in the implant site, an acceleration of the mechanisms of tissue regeneration was obtained; then, the implant was placed.

In the 11 cases who had received grafting of deantigenated, demineralized bovine bone called Geistlich Bio-Oss ® (mixed with 50% of cortical and medullary grafts and 50% of pure-phase beta-tricalcium phosphate) and Sint Oss made by “Industrie Biomediche e Farmaceutiche” with the addition of growth factors of PRP, we noticed a rapid regeneration and bone maturation and,